Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as a proto-oncogene in multiple cancers.The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype tumor-associated macrophages (M2 TAMs).However, we found here that the CSF1R expression was abnormally down-reg